gastro-intestinal tract is the grate obstacle for the attack outside and only one cell thick.
Our digestive tract is the grate defensive barrier to the outside attack. It is vulnerable to stress, foreign food proteins and bad bacteria. The lining of the digestive tract is protected by a single layer of epithelial cells. In small These are called enterocytes and in the colon they are called colonocytes. The small intestine is long enough to wrap around your waist about eight times whereas your colon is about as long as you tall.
irritable bowel syndrome (IBS), the most common diseases of the digestive system, can be an inflammatory disease of the intestine caused by stress and leaky gut.
Irritable bowel syndrome is reportedly the most common gastrointestinal disorders. We need to start from diarrhoea predominant irritable bowel syndrome (IBS-D), a disease caused by stress, diet and good or bad bacteria induced intestinal irritation leaky gut. The Good, Guilarte et al. from Barcelona, Spain report slightly increased intra-epithelial lymphocytes (IELs) and marked increases mast cells in patients with diarrhea predominant IBS, also had higher than normal psychological stress volunteers.
allergy cell, the mast cell, can be seen as Link to many causes of IBS, but requires special intestinal spots.
A stress mast cell axis has been suggested for a possible cause of IBS. Mast cells release of chemicals in response to triggers such as allergies and parasites normally in the body but have been associated with stress. Increased mast cells in the large and small intestines of patients with IBS especially when a blot on tryptase, an enzyme specific to mast cells, performed.
mast cells could lead to leaks leading to increased well Pain and diarrhea in IBS.
Mast cells can increase intestinal permeability (cause intestinal leaks), increased visceral sensitivity (increased feeling of pain and intensity) and increase the mobility (contractions of the intestines). This leads to diarrhea and abdominal pain.
increase in lymphocytes found may explain the link to gluten in IBS.
The finding an increased intraepithelial lymphocytes or lymphocytosis in the patients of this latest study was of particular interest to me. I see this very often in my patients who do not meet criteria for celiac disease or a gluten-free diet, previously labeled IBS. Sometimes I find that in small biopsies and sometimes in the colon of the patient. Some have a colonoscopy in the past, but no biopsies have been carried out because the colon "looked normal". In a recent post I did a study noted that the definition of IBS symptoms in more than 50% of patients with microscopic colitis.
Is your stomach and intestinal contents attacked and cause diseases?
If You are not experiencing optimal health, the proposition that our digestive tract is now under constant attack and is often not as a defensive barrier. Our enemies are increasingly seem to be genetically modified or prepared foods and bad bacteria. The bad bacteria have excess capacity because of hygiene practices and liberal use of antibiotics. Our defence must also be examined dietary changes such as reduction or elimination of gluten, organic food to eat, and the liberal use of probiotics supplements.
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Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum.
Guilarte, M et al. Gut February 2007; 56:203-209.
The Food Doc, Dr. Scot Lewey, is an expert medical doctor specializing in digestive diseases and food related illness, especially food allergies, celiac disease and colitis. Dr. Lewey's expert reputation as the Food Doc is established by a foundation of formal training in internal medicine, pediatrics, and gastroenterology (diseases of the digestive tract), his personal and family experience with gluten and milk sensitivity, and over two decades as a practicing physician, clinical researcher, author and speaker. Access this expert knowledge online today at http://www.thefooddoc.com
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